The Download: Montana’s new experimental drug rules

《下载》：蒙大拿州的新实验性药物法规

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. 这是今日份的《下载》，我们平日更新的简报，为您提供每日科技世界的动态。

Montana’s plan to become an experimental medical hub just pushed forward. As of this week in Montana, biotech companies whose drugs have been through preliminary testing—sometimes in as few as 10 healthy people—can pay $12,500 to apply to a newly established review board for approval. Once its treatment is rubber-stamped, the company can sell it via experimental treatment clinics, the first of which is likely to be up and running around the end of this year. 蒙大拿州成为实验性医疗中心的计划刚刚向前推进了一步。从本周开始，在蒙大拿州，那些药物已通过初步测试（有时仅在 10 名健康人身上进行过测试）的生物技术公司，可以支付 12,500 美元向新成立的审查委员会申请批准。一旦其治疗方案获得批准，该公司就可以通过实验性治疗诊所进行销售，首批诊所预计将于今年年底左右投入运营。

Montana’s latest right-to-try legislation is unique. Access to drugs is theoretically available to anyone who gives informed consent and can pay. For some, especially people in the longevity community, that’s a hopeful and exciting prospect. But to others, it’s unethical and dangerous. Read our story to learn about where this may all be headed. —Jessica Hamzelou 蒙大拿州最新的“尝试权”立法非常独特。理论上，任何签署知情同意书并能支付费用的人都可以获得这些药物。对于一些人，尤其是长寿社区的人来说，这是一个充满希望且令人兴奋的前景。但对另一些人而言，这是不道德且危险的。阅读我们的报道，了解这一切可能走向何方。——Jessica Hamzelou

Montana’s new “right to try” law can’t come soon enough for some. Kris DeVault is desperate. His son, Brody, born in March 2023, has something called creatine transporter deficiency—a rare condition in which the brain and muscles lack the energy they need to develop. There are no cures for Brody’s condition. But DeVault has learned of a company developing a drug that might help. That drug is still in the early stages of development and has only been tested in animals and a small number of healthy adults. Doctors can’t prescribe it. DeVault knows the drug might not work. But he’s doing all he can to access it regardless. Read our story about DeVault’s efforts. —Jessica Hamzelou 对于一些人来说，蒙大拿州新的“尝试权”法律出台得越快越好。Kris DeVault 心急如焚。他出生于 2023 年 3 月的儿子 Brody 患有一种名为“肌酸转运蛋白缺乏症”的罕见疾病，导致大脑和肌肉缺乏发育所需的能量。目前 Brody 的病情尚无治愈方法。但 DeVault 得知有一家公司正在开发一种可能有帮助的药物。该药物仍处于早期开发阶段，仅在动物和少数健康成年人身上进行过测试。医生无法开具处方。DeVault 知道这种药可能无效，但他仍竭尽全力试图获取它。阅读我们关于 DeVault 努力的报道。——Jessica Hamzelou

This story is from The Checkup, our weekly biotech newsletter. Sign up to receive it in your inbox every Thursday. 本文摘自我们的每周生物技术简报《The Checkup》。订阅即可在每周四收到邮件。

The must-reads

必读内容

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology. 我梳理了互联网，为您找出了今天关于科技的最有趣、最重要、最可怕和最引人入胜的故事。

Anthropic says its models hacked external organisations during testing. It was prompted to conduct a review after similar issues at OpenAI. (TechCrunch)
Anthropic 表示其模型在测试期间入侵了外部组织。 在 OpenAI 出现类似问题后，该公司被要求进行审查。（TechCrunch）
Europe is bracing itself for an even more fiery future. Countries like France and Spain can expect regimes akin to those in California. (Nature)
欧洲正为更加火热的未来做准备。 法国和西班牙等国可能面临类似于加利福尼亚州的气候状况。（Nature）
Drone warfare is making the skies more dangerous. A fatal plane accident in the US this May, caused by a military GPS jamming exercise, may signal what’s to come. (Wired)
无人机战争使天空变得更加危险。 今年 5 月美国发生的一起致命飞机事故是由军事 GPS 干扰演习引起的，这可能预示着未来的风险。（Wired）
As Big Tech’s AI spending grows, so do the jitters. Amazon, Google, Meta and Microsoft are set to invest $1.5 trillion into AI infrastructure. But who will pay for it? (NYT)
随着大型科技公司 AI 支出的增长，焦虑感也在增加。 亚马逊、谷歌、Meta 和微软计划在 AI 基础设施上投资 1.5 万亿美元。但谁来买单？（NYT）
How China has changed the sovereign AI playbook. Kimi 3 from Moonshot makes forking out for expensive US models seem foolish. (Rest of World)
中国如何改变了主权 AI 的策略。 月之暗面（Moonshot）的 Kimi 3 让人们觉得花大价钱购买昂贵的美国模型显得很愚蠢。（Rest of World）
Google’s Gemini can now control a humanoid robot. It was previously restricted to upper body movements. Now, it can manage the entire range of motion. (Bloomberg)
谷歌的 Gemini 现在可以控制人形机器人。 此前它仅限于上半身动作，现在它可以管理全身的运动范围。（Bloomberg）
Amazon says it’s found “catastrophically expensive” AI cost overruns. It’s far from alone—and that’s why the “tokenmaxxing” trend disappeared so quickly. (FT)
亚马逊称发现了“灾难性昂贵”的 AI 成本超支。 这绝非个例，这就是为什么“tokenmaxxing”（最大化 Token 使用）趋势消失得如此之快的原因。（FT）
How a remote indigenous community built a super fast fiber network. It was a complex, expensive endeavor. But it now outperforms Starlink. (IEEE Spectrum)
一个偏远的土著社区如何建立了一个超高速光纤网络。 这是一项复杂且昂贵的工程，但它现在的表现优于星链。（IEEE Spectrum）
Meet Wikipedia’s most diligent editor. Steven Pruitt is unremarkable in some ways—yet truly amazing in others. (New Yorker)
认识一下维基百科最勤奋的编辑。 Steven Pruitt 在某些方面平平无奇，但在其他方面却令人惊叹。（New Yorker）
You can now report AI slop with a button on LinkedIn. The people have spoken. And they are tired of reading bland nonsense. (404 Media)
现在你可以在 LinkedIn 上通过按钮举报 AI 生成的垃圾内容。 民意已达，人们厌倦了阅读平淡无奇的废话。（404 Media）

Quote of the day

今日名言

“It’s a shock, thinking that just an hour earlier I’d been in my room and everything… and now, there’s nothing left.” —18-year-old Raphael Fohanno tells Reuters his reaction to wildfires destroying his parents’ house in the French town of Biscarrosse. “这太令人震惊了，想到就在一小时前我还在自己的房间里，一切都好好的……而现在，什么都没了。”——18 岁的 Raphael Fohanno 在接受路透社采访时，描述了他对野火摧毁其父母在法国比斯卡罗斯镇房屋的反应。

One More Thing

补充一点

Congress used to evaluate emerging technologies. Let’s do it again. The US Office of Technology Assessment (OTA), an independent office created by Congress in the early 1970s, produced some 750 reports during its 23-year history, assessing technologies as varied as electronic surveillance, genetic engineering, and remote sensing from outer space. The office functioned like a debunking arm. It sussed out the snake oil. Its reports saw through the alluring gleam of overhyped technologies. Since its unceremonious defunding in 1995, perennial calls have gone out: Rouse the office from the dead! Read our story about why, with advances in robotics, big data, and AI systems, these calls have taken on a new level of urgency. —Peter Andrey Smith 国会曾经评估过新兴技术，让我们重拾这一做法。美国国会技术评估办公室（OTA）是国会在 20 世纪 70 年代初设立的一个独立机构，在其 23 年的历史中撰写了约 750 份报告，评估了从电子监控、基因工程到太空遥感等各种技术。该办公室发挥着“辟谣”部门的作用，它能识破“江湖骗术”，其报告能看穿被过度炒作的技术那诱人的光环。自 1995 年被草率地停止拨款以来，人们不断呼吁：让这个办公室起死回生吧！阅读我们的报道，了解为什么随着机器人、大数据和 AI 系统的进步，这些呼声变得愈发紧迫。——Peter Andrey Smith

We can still have nice things

我们依然可以拥有美好事物

A place for comfort, fun, and distraction to brighten up your day. 一个为您带来舒适、乐趣和放松，点亮您一天的地方。

Fencing on roller skates is the self-defense you didn’t know you needed.
穿着旱冰鞋击剑是你意想不到的防身术。
Meet Pumpkin, a chubby cat that’s in no mood to lose weight.
认识一下 Pumpkin，一只完全不想减肥的胖猫。
Discover what the animals near you are probably doing right now at Nature This Week.
在《本周自然》中发现你身边的动物们现在可能在做什么。
Woodworker extraordinaire Matt Thompson has installed a model railroad that runs along his fence.
木工大师 Matt Thompson 安装了一条沿着他家围栏运行的火车模型轨道。